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Biochim Biophys Acta 1778:357375

Vitamin D3-mediated activation of both TXNRD1 and GSH biosynthesis could substantially counteract the proteolytic knockdown of TXNRD1 and GCLC predicted by our hypothesis , which, if validated, would thus represent an important mechanism contributing to a role for vitamin D3 in moderating the severity of COVID-19

In the GCH1-BH4 pathway, BH4 functions as an antioxidant capable of trapping peroxidized lipid radicals, with GCH1 serving as the rate-limiting enzyme in BH4 biosynthesis